Sedative medicines for instance benzodiazepines or associated medication: The concomitant use of opioids with sedative medicines such as benzodiazepines or linked medications enhances the threat of sedation, respiratory despair, coma and death thanks to additive CNS depressant effect. The dose and length of concomitant use really should be constrained (see https://anciusr008bqd1.blogadvize.com/profile