Chemotherapy was potentiated by E7449 and single agent had important antitumor exercise in BRCA-deficient xenografts. In addition, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell traces, possible by means of TNKS inhibition. Per this probability, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and significantly altered expression of Wnt https://barrettn429eko3.popup-blog.com/profile