- Upper limits generally prompting referral are opioids in combination that exceed a complete everyday dose > 90 MME/day. Look at buprenorphine. For patients with opioid use problem, conversion from other opioids to buprenorphine can offer a safer substitute even though however providing the benefits, if any, of opioid analgesia. http://greentornado.com/directory/listingdisplay.aspx?lid=64240