Conolidine’s analgesic effects stem from its interaction with non-opioid pain pathways. Unlike opioids, which bind to µ-opioid receptors inside the central nervous system, conolidine modulates alternate molecular targets. A Science Innovations study identified that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. By in... https://conolidinealleviatemyback46789.blogzag.com/81544053/what-does-alternative-natural-pain-relief-to-replace-traditional-painkillers-mean